Lung Cancer Cell Lines

Through the removal and culturing of cancerous lung tissue in the explanted tumor of a 58 year old caucasian male.

Lung cancer cell lines.

Small cell lung cancer project site navigation project documentation data downloads. The cells are used as models for the study of lung cancer and the development of drug therapies against it. Lung cancer and normal cell lines atcc no. Non small cell lung cancer is an umbrella term for several types of lung cancers.

Once tumors demonstrated growth in a non self host cell lines were established. A549 cells are adenocarcinomic human alveolar basal epithelial cells and constitute a cell line that was first developed in 1972 by d. Cancer cell lines with mutant kras genes the heterogeneity of human cancers is a major obstacle to developing therapies. Non small cell lung cancer homo sapiens 59 yrs caucasian crl 2868 hcc827 lung epithelial adenocarcinoma homo sapiens.

Successful cell lines were evaluated for the ability to produce orthotopic lung tumors in immunocompetent hosts. Browse squamous cell adenocarcinoma sclc and nsclc cell lines for drug response toxicology in vitro models including a549 nci h292 and more. By default data for all cell lines will be retrieved though search results can be restricted by panels or cell lines in the next part of the form. When you inhale cigarette smoke which is full of cancer causing substances carcinogens changes in the lung tissue begin almost immediately.

Lymph node 3b adenocarcinoma. 1 3 despite response rates of 60 to 65. We compared a variety of properties of 12 human non small cell lung carcinoma nsclc cell lines. We produced six murine lung cancer lines capable of orthotopic lung tumor formation in immunocompetent c57bl 6 animals.

Physiologically relevant controls. Select lung cancer cell lines authenticated by ecacc based on associated mutations and diagnosis classifications. Non small cell lung cancer. Although human lung tumor derived cell lines play an important role in the investigation of lung cancer biology and genetics there is no comprehensive study comparing the genotypic and phenotypic properties of lung cancer cell lines with those of the individual tumors from which they were derived.

Lung cancer cell lines eml4 alk fusion a549 a549. One way of dealing with that heterogeneity is to test large numbers of patient derived cell lines for common vulnerabilities. Standard of care first line treatment for extensive stage small cell lung cancer is platinum chemotherapy carboplatin or cisplatin with etoposide. Name tissue cell type disease oganism age ethnicity genes expressed crl 5844 nci h838 h838 lung.